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调控血脂改善脑梗死患者血管内皮功能的研究 被引量:12

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摘要 目的 研究降低血脂水平对改善脑梗死患者内皮依赖性血管舒张功能的影响。方法 给 33例脑梗死患者口服普伐他汀 2 0mg,每日 1次 ,连续服 6周 ,观察治疗前后血脂及颈内动脉内皮依赖性血管舒张功能的变化 ,并与对照组比较。结果 治疗 6周后 ,普伐他汀组胆固醇、低密度脂蛋白胆固醇明显降低 (分别降低 2 6 9%和 2 5 8% ) ,与治疗前比较差异有显著性 (均P <0 .0 1) ;对照组血脂各项指标虽有降低 ,但与治疗前比较差异无显著性 (均P >0 .0 5 )。颈动脉内皮依赖性血管舒张功能治疗前后普伐他汀组差异有显著性 ,对照组差异无显著性。结论 普伐他汀对脑梗死患者的血脂水平和血管内皮舒张功能均有明显改善作用。
机构地区 解放军
出处 《临床神经病学杂志》 CAS 2004年第2期135-136,共2页 Journal of Clinical Neurology
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