慢性脑缺血与认知功能障碍

Chronk Cerebral Ischemia and Cognitive Impairment

慢性脑缺血是一种常见的病理状态,伴发于多种脑血管病的病理过程中。许多临床和实验室证据都表明,慢性脑缺血能引起认知功能障碍。目前的研究认为,慢性脑缺血能够引起能量代谢障碍、葡萄糖利用减少、蛋白质合成异常、神经递质改变、胆碱能受体缺失、脑白质损害和神经元缺陷等,构成了导致认知功能损害的病理生理基础:

Chronic cerebral ischemia is a common pathological status, it accompanied with many cerebrovascular diseases in the pathological processes. Much clinical and experimental evidence have showed that chronic cerebral ischemia could cause cognitive impairment. The present researches consider that chronic cerebral ischemia may cause the energy metabolism disturbance, the decrease of glucose utilization rate, the abnormality of protein synthesis, the change of neuro-transmitter, the cholinergic receptor defects, the brain white matter lesions and the neuronal defect, etc. They constitute the pathophysiological basis of cognitive impairment.