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转铁蛋白受体介导的药物转运在急性脑梗死治疗中的应用 被引量：1

Application of the Transferrin Receptor-mediated Drug Delivery Systems in the Treatment of Acute Cerebral Infarction
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摘要 在急性脑缺血的超早期,完整的血脑屏障(BBB)使许多治疗药物无法在有效治疗时间窗内进入脑组织发挥作用。转铁蛋白受体(TfR)单克隆抗体能有效通过受体介导的细胞内吞作用使结合的药物通过BBB,从而大大增加了治疗药物的定向选择性,使之更好地发挥治疗作用。 In the super early phase of acute cerebral ischemia, many therapeutic drugs cannot penetrate into the complete blood-brain barrier (BBB) and enter brain tissues within the effective time window. The transferrin receptor(TfR) monoclonal antibodies can effectively penetrate BBB via receptor-mediated endocytosis and make the combined drugs penetrate BBB, and thus increasing the orientation selectivity of the therapeutic drugs considerably, and developing their better therapeutic effect.
作者 温仲民 包仕尧 钱忠明
机构地区 苏州大学附属第二医院神经内科 香港理工大学应用与化学技术系
出处 《国外医学（脑血管疾病分册）》 2004年第4期301-303,共3页 Foreign Medical Sciences Cerebrovascular Diseases
关键词 转铁蛋白受体 药物转运 急性脑梗死 药物治疗 单克隆抗体 血脑屏障 transferrin cerebral infarction blood-brain barrier monoclonal antibodies
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献10

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国外医学（脑血管疾病分册）
2004年 第4期

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