1Murray C.J. and A. D Lopez. Alternative propections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet, 1997,349:1498～ 1504
2Burrows B. Predictors of loss of lung function and mortality in obstructive lung disease. Eru Respir Rev, 1991,1:340～ 345
3Saetta M,Turato G,Maestrelli P,et al. Cellular and structural bases of chronic obstructive pulmonry disease. Am J Respir Crit Care Med, 2001 , 163:1304 ～ 1309
4Balbi B, Majori M, Bertacco S, et al. Onhaled corticosteroids in stable COPD patients:do they have effects on cells and molecular mediators of airway inflammation? Chest, 2000,117 : 1633 ～ 1637
5Yildiz F,Kaur A,Ilgazli A,et al. Inhaled corticosteroids may re duce neutrophilic inflmmation in patients with stable chronic obstructive pulmonary disease. Respir, 2000,67: 71 ～ 7 6
6Hattotuwa K,Gizycki MJ,Ansari TW,et al. The dffects of in haled fluticasone on airway inflammation in chronic obstructive pulmonary disease. Am J Resepir Crit Care Med, 2002,165:1595 ～1596
7Confalonieri M,Mainardi E,Della P,et al. Inhaled corticosteroids reduce neutrophilic bronchial inflammation in patients with chron ic obstructive pulmonary disease. Thorax, 1998,53: 583 ～ 585
8Llewellyn-Jones C, Harria T, Stockley R. Effect of fluticasone propionate on sputum of patients with chronic bronchitis and em physema. Am J Respir Crit Care Med, 1995,153: 61 6 ～ 621
9Keatings VM,Jatakanon A,Worsdell Y,et al. Effects of inhaledand oral glucocorticoids on inflammatory indices in asthma and COPD. Am J Respir Crit Care Med, 1996:153:616 ～ 621
10Culpitt SV,Maziak W,Loukidis S,et al. Effect of high dose in haled steroid on eell,cytokines,and proteases in induced sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med,1999:115～31
