新疆静脉吸毒者中TTV、HBV和HCV感染情况分析

Analysis of TTV,HBV AND HCV intravenous in intravenous drug users in Xinjiang

目的:探讨新疆静脉吸毒者中输血传播病毒 (TTV)、乙型肝炎病毒 (HBV)、丙型肝炎病毒 (HCV)感染的特点 ,为防止感染提供理论依据。 方法:采用套式 PCR技术检测 10 2例静脉吸毒者 (IVDUs)血清中 TTV-DNA,用酶联免疫吸附试验 (EL ISA)检测 HCV抗体 (抗 HCV)及 HBV血清学标志物 ,根据 TTV- DNA检测结果分为 TTV - DNA阳性组和阴性组 ,比较两组人群的 HBV、HCV及 HBV/HCV感染情况。结果:静脉吸毒者 TTV-DNA阳性组和阴性组在民族、年龄、性别、吸毒时间、吸毒剂量、有无多性伴侣、HCV和 HBV病毒混合感染等方面无统计学差异 ,而在是否共用注射器上差异有统计学意义 (P <0 .0 5 )。 33例 TTV- DNA阳性静脉吸毒者中 ,7例为单纯 TTV感染 ,2 6例重叠 HCV或 HBV感染 ,其中 TTV、HCV、HBV三重感染 8例。结论 :TTV、HCV在新疆静脉吸毒者中有较高的阳性率 ,静脉吸毒人群是 TTV、HCV感染的高危人群。 TTV可以单独感染 ,但与 HBV、HCV的重叠感染率也较高。

Objective: To study the status and factors of transfusion transmitted virus (TTV), HBV and HCV infection among intravenous drug users (IVDUs) of Xinjiang and probe into the scientific method to prevent them. Methods: Serum samples from 102 IVDUs in Xinjiang were examined for TTV DNA by nested polymerase chain reaction (nPCR), the seroprevalence of viral markers of HBV and HCV infection was also examined by ELISA. Results: There was no relationship between TTV infection with nationalities、sex、age and persisted time of intravenous drug users. Eight of 33 cases with TTV infection for both anti HCV and serological markers of HBV, Seventeen were positive for anti HCV, One was positive for markers of HBV infection. Conclusion: The research proves that the infection of TTV and HCV is rather comprehensive in IVDUs of xinjiang. The IVDUs are high danger crowd, TTV super infection with hepatitis C and hepatitis B appeared to be associated with a same transmitted route among IVDUs.