甲状腺癌中ER、PR和p53表达的病理生物学意义

Analysis of immunohistochemical study of expression of the estrogen receptor (ER) progesterone receptor (PR) and p53 in thyroid carcinoma and related pathologic significance

目的:检测并分析甲状腺癌中 ER、PR和 p5 3表达与临床病理特点的关系。 方法:应用 SABC免疫组化法检测 32例甲状腺癌和 30例甲状腺瘤中 ER、PR和 p5 3的表达。结果 :甲状腺癌中 ER、PE、p5 3阳性表达率分别为 5 6 .2 %、5 3.1%、37.5 % ;甲状腺瘤中 ER、PE阳性表达率分别为 6 6 .7%、73.3% ,p5 3无表达。甲状腺腺癌中p5 3表达明显个高于甲状腺瘤 ;分化好的甲状腺乳头状腺癌中 ER、PR表达明显高于分化差的滤泡状癌。 结论 :ER、PR的高表达和 p5

Objective: To study the relationship between the expression of ER PR and p53 protein and clinicopathologic properties in thyroid carcinoma. Methods: The expression of ER、PR and p53 protein in 32 cases with thyroid carcinoma and in 30 cases of thyroid adenoma were examined using SABC immunohistochemical method. Result: The positive expression of ER PR and p53 protein in thyroid carcinoma was 56.2%, 53.1%, 37.5% respectively, the positive expressions of ER and PR were 66.7%, 73.3%, There was no expression in thyroid adenoma. Expression of ER and PR was no significant difference between carcinoma and adenoma, but the positive rate of p53 protein in carcinoma was significantly higher than in adenoma. Expression of ER and PR, which were higher in papillary carcinoma of thyroid than in follicular carcinoma. Conlusions: The results suggest that ER PR overexpression、p53 protein low expression might be used as the markers to evaluate good prognosis.