老年消化系统恶性肿瘤患者血清肿瘤标记物临床应用分析

The clinical application analysis of serum tumor markers in elderly with malignant tumor of digestive system

目的 探讨血清CEA、AFP、CA19-9、CA724对老年人消化系统恶性肿瘤的诊断价值。方法 采用ELISA方法对 155例老年良性疾病患者、214例老年消化系统恶性肿瘤患者、236例非老年消化系统恶性肿瘤患者进行CEA、AFP、CA19-9、 CA724检测。结果老年胰腺癌、胆管癌患者CA19-9阳性率高,分别为84％、75%,老年胃癌、大肠癌、食管癌患者CEA、CA19- 9、CA724联合检测阳性率为41％、65％、10％,老年原发性肝癌患者AFP、CA19-9联合检测阳性率为69％。结论 CA19-9适用 于老年人胰腺癌、胆管癌的诊断,AFF、CA19-9联合检测可提高老年原发性肝癌患者检测阳性率,CEA、CA19-9、CA724联合检测 可提高老年人胃癌、大肠癌的阳性率,而对老年人食管癌的诊断价值有限。

Objective To investigate the diagnostic value of serum CEA,AFP,CA19-9,CA724 in elderly with malignant tumor of digestive system.Methods We detected serum CEA,AFP、CA19-9、CA724 in 155 elderly patients with benign diseases,214 elderly and 236 non-elderly patients with malignant tumor of digestive system. Results The positive rate of CA19-9 in elderly patients with pancreatic carcinoma and cholangiocarcinoma was high,and it was 84% and 75% respectively.The positive rate of CEA,CA19-9 and CA724 in combination in elderly patients with gastric carcinoma,colonorectal carcinoma and esophageal carcinoma was 41% ,65% and 10% respectively.The positive rate of AFP and CA19-9 in combination in elderly patients with primary carcinoma of liver was 69% . Conclusions CA19-9 was suitable for diagnosis of elderly patients with pancreatic carcinoma and cholangiocarcinoma. AFP and CA19-9 combination examination can increase positive rate in elderly patients with primary carcinoma of liver. CEA, CA19-9 and CA724 combination examination can increase positive rate in elderly patients with gastric carcinoma and colonorectal carcinoma,but it has only limited diagnostic usefulness in elderly patients with esophageal carcinoma.