胺碘酮对老年心动过缓伴室性早搏临床疗效的观察

The therapeutic effect of amiodarone on the elderly with sinus bradycardia and premature ventricular complexes

目的 观察胺碘酮对老年心动过缓伴室性早搏的临床疗效。方法选择老年心动过缓伴室性早搏患者29例, 入选者均为其它抗心律失常药物治疗效果欠佳或出现明显不良反应,口服胺碘酮4周并复查动态心电图、甲状腺功能、肝功、 胸片等。结果显示口服胺碘酮后总有效率86.20％,用药后平均心率减慢,QTc延长,不良反应发生率为20.69％。结论 胺 碘酮治疗老年心动过缓伴室性早搏相对较安全、有效。

Objective To detect the therapeutic effect of amiodarone on the elderly with sinus bradycardia and premature ventricular complexes. Methods 29 old patients with sinus bradycardia and premature ventricular complexes were enrolled. All patients were previously treated with other antiarrhythmia drugs. Those subjects did not persist in taking these medicine because of side effect or without effect. All subjects taked amiodarone for four weeks.After that,we checked all patients' ECG、liver function、thyroid function and chest X-ray. Results The total availability of amiodarone was 86.2 percent on those patients. Mean heart rate was decreased and QTc prolonged after taking medicine. The incidence of side effect was 22.69 percent. Conclusions Amiodarone was safe and effective on the elderly with sinus bradycardia and premature ventricular complexes.