精灵口服液治疗精索静脉曲张不育手术后的临床观察

Clinical Observation on Effect of Jingling Oral Liquid in Treating Infertile Patients with Varicocele after Varicocelectomy

目的 观察精灵口服液对精索静脉曲张不育手术后治疗的临床疗效。方法将手术后精索静脉曲张不育的60例患者随机分成两组,治疗组(30例)口服精灵口服液,对照组(30例)肌肉注射绒毛膜促性腺激素(hCG)。结果 配偶受孕率治疗组为76.6％,对照组为40.0％,两组比较差异有显著性(P<0.05);两组治疗后精液质量较治疗前均显著提高(P<0.05或P<0.01),且治疗组优于对照组(P<0.05);两组生殖内分泌激素治疗后均有改善(P<0.01);治疗组治疗后精浆超氧化物歧化酶、精浆锌显著提高,精浆镉下降,与治疗前比较差异均有显著性(P<0.05)。结论 精灵口服液对精索静脉曲张不育术后患者有改善和调节生殖内分泌激素失调,提高精浆与精子质量,增加配偶受孕率的作用。

To observe the clinical effect of Jingling oral liquid (JLOL) in treating infertile patients with varicocele after varicocelectomy. Methods Sixty patients were randomly divided into two groups, the 30 patients in the treated group treated by JLOL, and the 30 in the control group treated with intramuscular injection of human chorionic gonadotropine (hCG). Results The pregnant rate of patient's wife in the treated group was 76.6% , while that in the control group was 40.0% , showing significant difference between them (P< 0.05). The quality of semen was improved in both groups (P<0.05 or P<0.01), and the improvement was better in the treated group than that in the control group (P<0.05). The reproductive hormones were also improved in both groups (P<0.01). In the treated group, levels of superoxide dismutase (SOD) and zinc in semen increased, and that of cadmium decreased after treatment, as compared with those before treatment, the difference was significant (P<0.05). Conclusion JLOL could improve and regulate the reproductive hormone disturbance in infertile patients with varicocele after varicocelectomy, enhance their quality of semen and sperm to increase the pregnancy rate of their spouses.