乳宁Ⅱ号对TA2小鼠乳腺癌MA-891移植瘤中血管内皮生长因子表达的影响

Effect of Riming Ⅱon Expression of Vascular Endothelial Growth Factor in Transplanted Tumor of Mammary Cancer MA-891 in TA2 Mice

目的 研究乳宁Ⅱ号对TA2小鼠乳腺癌移植瘤中血管内皮生长因子(VEGF)表达及肺转移的影响。方法 将体外培养的MA-891小鼠乳腺癌细胞接种于TA2小鼠右腋部皮下,造成小鼠移植瘤肺转移模型,同时予乳宁Ⅱ号治疗。结果 乳宁Ⅱ号可抑制移植瘤生长,减少肺转移的发生(P<0.05),降低肿瘤组织中VEGF蛋白及VEGF mRNA表达(P<0.05)。结论 乳宁Ⅱ号可通过降低肿瘤组织中VEGF蛋白及VEGF mRNA表达,发挥抑瘤和抗转移作用。

To study the effect of Runing Ⅱon expression of vascular endothelial growth factor (VEGF) in transplanted tumor of mammary cancer MA-891 in TA2 mice. Methods The MA-981 mice mammary cancer cell cultivated in vivo was inoculated into the right axilla subcutaneously of TA2 mice to establish the transplanted tumor model, which were treated with Runing Ⅱ. Results Runing Ⅱ could inhibit the growth of transplanted tumor and the occurrence of lung metastasis (P<0.05), reduce the expression of VEGF protein and mRNA in tumor tissue (P<0.05). Conclusion Runing Ⅱ could reduce the expression of VEGF protein and mRNA, hence to inhibit the growth of tumor and lung metastasis.