放化疗治疗中晚期宫颈癌32例总结

Treatment with Concurrent Chemotherapy and Radiotherapy for 32 Cases of Advanced Cervical Cancer

[目的]观察放化疗治疗中晚期宫颈癌的疗效及毒副反应.[方法]32例Ⅱb～Ⅲ期宫颈癌患者放疗同时并用VBP方案化疗,另配对选取同期收治的32例单纯放疗者作为对照组.放疗方法采用规范、全量根治性治疗:体外照射加腔内后装治疗.[结果]所有病例如期完成治疗.结束后3个月综合组有效率90.63%,单放组为54.17%,两组相比差异有显著性(P＜0.05).3年生存率综合组84.38%,单放组53.13%,综合组生存率优于单放组(P＜0.05).综合组疗效明显高于放疗组.综合组的毒副反应主要为骨髓轻度抑制和恶心、呕吐等肠道反应,但均为可逆,所有患者都按时完成放射治疗.[结论]放疗同时配合VBP化疗方案治疗宫颈癌,有利于提高中、晚期宫颈癌的3年生存率,其毒副反应可以耐受.

To observe and evaluate the result of the advanced cervical cancer treated with con-current chemotherapy and radiotherapy(CCR).Thirty-two cases with advanced cervical cancer(stageⅡb toⅢ)were treated with concurrent chemotherapy and radiotherapy(group A).Chemotherapy consisted of VCR,DDP and PYM.Full dose of external irradiation combined with intracavitary radiation was adopt.Thirty-two cases(group B)in the same period treated with radiotherapy alone served as con-trols.After3months'treatment,response rate(CR+PR)in group A was90.63%,while in group B was54.17%(P<0.05).The3-year survival rate in group A was84.38%,while in group B was53.13%.The result of CCR was significantly better than that of conventional radiotherapy.The major side effects in group A were mild leucopoenia,appetite,nausea and vomiting.But toxicity due to chemotherapy was usu-ally reversible.All patients could complete the treatment plans in time.[Conclusions]Chemotherapy with VBP and regimen concurrent radiation therapy may improve the3-year survival rate of advanced cervical cancer,the toxicity are tolerable.