2Peutz J L. A very remarkable case of fa- milial polyposis of mucous membrane of intestinal tract and nasophary accom- panied by peculiar pigmentation of skin and mucous membrane[J]. Ned Maan- dschr,1921,10:134-146.
3Jeghers H, Mckusick V A, Katz K H. Generalized intestinal polyposis and melanin spots of rhe ora~ mucosa, lips and digits[J]. N Engl J Med, 1949,241:993-1005.
4Aretz S, Stienen D, Uhlhaas S, et al. High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome[J]. Hum Mutat, 2005, 26(6):513-519.
5Hemminki A, Markie D, Tomlison I, et al. A serine/threonine kinase gene defective in Peutz-Jegheres syndrome[J]. Nature, 1998,391 (2): 184-187.
6Jenne D E, Reimann H, Nezu J, et al. Peutz Jeghers syndrome is caused by mutations in a novel serine threonine ki- nase[J]. Nature Genetics, 1998,18:38-43.
