摘要
Objective:To investigate the changes of brain derived neurotrophic factor(BDNF) in hippocampus of chronic lead exposed rats.Methods:Wistar rats were exposed to lead by drinking 0 02%、0 2% l ead acetate solution for three months,respectively.Investigate the changes of le arning and memory ability by Y-labyrinth experiment,study the changes of BDNF p ositive neuron in CA 1,CA 3 and dentate gyrus in hippocampus of rats by immun ohistochemistry.Results:BDNF positive neurons distribute everywhere in the hippocamp us under normal condition.Compared with the contral group,the number of BDNF pos itive neurons in the hippocampus subregions were decreased significantly of two different dosage(0 02%,0 2%) chronic lead exposed groups(P<0 05). Conclusion:These results suggest that the reduction of BDNF positive neuron in hippocampus might be related to the impact of lead on learning and me mory.
Objective:To investigate the changes of brain derived neurotrophic factor(BDNF) in hippocampus of chronic lead exposed rats.Methods:Wistar rats were exposed to lead by drinking 0 02%、0 2% l ead acetate solution for three months,respectively.Investigate the changes of le arning and memory ability by Y-labyrinth experiment,study the changes of BDNF p ositive neuron in CA 1,CA 3 and dentate gyrus in hippocampus of rats by immun ohistochemistry.Results:BDNF positive neurons distribute everywhere in the hippocamp us under normal condition.Compared with the contral group,the number of BDNF pos itive neurons in the hippocampus subregions were decreased significantly of two different dosage(0 02%,0 2%) chronic lead exposed groups(P<0 05). Conclusion:These results suggest that the reduction of BDNF positive neuron in hippocampus might be related to the impact of lead on learning and me mory.
出处
《武警医学院学报》
CAS
2004年第2期84-86,共3页
Acta Academiae Medicinae CPAPF
基金
国家自然科学基金项目 ( 39870 6 89)
关键词
慢性铅中毒
鼠
大脑
神经营养
影响因素
Hippocampus
Lead
Brain derived neurotrophic facfo r
Learning and memory
