p16蛋白和E-cadherin表达与鼻咽癌生物学行为的关系

Correlation between the Expression of p16 Protein and E-cadherin and Biological Behavior in Nasopharyngeal Carcinoma

目的:探讨p16蛋白和E-cadherin在鼻咽癌组织中的表达与其生物学行为的关系。方法:应用免疫组化技术检测p16蛋白和E-cadherin在鼻咽癌和鼻咽粘膜炎性组织中的表达。结果:鼻咽癌组织p16蛋白阳性表达率明显低于鼻咽粘膜炎组织(P<0.05),而两组之间E-cadherin的表达无显著性差异(P>0.05);Ⅰ、Ⅱ期患者p16蛋白和E-cadherin的阳性表达率高于Ⅲ、Ⅳ期患者,但无统计学差异(P>0.05);p16蛋白和E-cadherin表达与颈淋巴结转移、远处转移及放疗后复发和转移无明显相关(P>0.05)。结论:p16蛋白表达的缺失可能涉及鼻咽癌的发生、发展过程。E-cadherin表达与鼻咽癌生物学行为的相关性有待进一步研究证实。

Objective: To investigate the correlation between the expression of p16 protein and E-cadherin and clinic biological behavior in nasopharyngeal carcinoma (NPC). Methods: Immunohistochemical method was used to detect the expression of p16 protein and E-cadherin in NPC and inflammatory nasopharyngeal mucosa. Results: The positive expression rate of p16 protein in NPC was significantly lower than that in inflammatory nasopharyngeal mucosa (P<0.05), but this difference was not statistically significant in the expression of E-cadherin (P>0.05). The positive expression rate of p16 protein and E-cadherin in stageⅠand Ⅱ patients was higher than that in stage Ⅲ and Ⅳ patients, but no statistically significant difference was observed (P>0.05). The expression of p16 protein and E-cadherin did not correlate with lymph node metastasis, distant metastasis as well as post-radiotherapy tumor recurrence and metastasis (P>0.05). Conclutions: Reduced expression of p16 protein may play an important role in the development of NPC. Futher studies are necessary to determine the correlation between the expression of E-cadherin and biological behavior in NPC.