腋窝淋巴结微小转移与肿瘤微血管计数对乳腺癌患者预后的影响

Axillary Lymph Nodes Micrometastasis and Microvessel Count Influence on the Prognostic of the Patients with Breast Cancer

目的:通过对腋窝淋巴结阴性乳腺癌患者的淋巴结进一步分析,研究淋巴结微小转移灶及肿瘤微血管计数(MVD)对预后的影响。方法:选取1993年564例乳腺癌中腋窝淋巴结阴性患者48例(24例死亡,24例生存),分别用HE、EMA和CK19对原淋巴结病理切片进行复染,确定微小转移灶。将肿瘤病理切片用FVIII因子染色,确定微血管数目。结果:48例共882枚淋巴结中发现微小转移灶为9.0%(79/882),死亡组与对照组之间无显著差异(P>0.05);微血管计数两组之间差异有显著性意义(P<0.001),经统计学分析微血管计数对患者预后的判别能力大于淋巴结微小转移灶。结论:本研究中淋巴结微小转移灶未显示出对生存的明显影响,而肿瘤的微血管计数与腋窝淋巴结阴性乳腺癌患者的生存时间呈负相关。

Objective: By means of further analyzed to the patients of axillary lymph node-negative breast cancer, and study that the lymph nodes micrometastasis and the microvessel count of tumor influence on the prognosis of breast cancer. Methods: We re-examined 882 regional lymph nodes of 48 patients which documental no tumor cells by conventional histopathological examination from 48 of 564 female patients with the breast cancer in 1993 using immunohistochemical LSAB techniques. HE, anti-EMA, CK 19,and FVIII factor were used as the primary reagents to identify tumor cells both in lymph nodes and microvesssel count in tumor tissues. Results: Overall, immunostaining positive tumor cells were found in 9.0%(79/882) of the dissected lymph nodes, there are not significant difference between these two group (P>0.05). Microvessel count has obviously significant difference between these two group (P<0.001). This study was analysis by statistics, and showed that the distinguished ability of MVD was better than the lymph nodes micrometastases for patients' prognosis. Conclusions: The lymph nodes micrometastases have not show the effect of patients' survival in this study. The microvessel count of tumor with the survival time of the breast cancer with axillary lymph node-negative present negative correlation.