胆碱代谢PET显像的临床应用

The Clinical Application of Imaging Choline Metabolism With PET

2-18F-2-脱氧-D-葡萄糖(FDG)是一种常用的肿瘤正电子显像剂,但在鉴别诊断肿瘤时,很难区分炎症和肿瘤病灶,可能造成肿瘤诊断的假阳性结果。胆碱代谢正电子发射断层(PET)显像能够弥补FDG某些不足,已用于各类肿瘤的鉴别诊断,特别在前列腺癌、脑瘤和膀胱癌的鉴别诊断方面明显优于FDGPET。本文对胆碱代谢PET显像的基本原理、常用正电子显像剂及其临床应用进行了概述。

2-fluoro-2-deoxy-D-glucose (FDG) is the most widely used agent for imaging tumors with positron emission tomography (PET). However, diagnosis of malignant tumors with FDG PET can create a relatively high false positive ratios, which is based on the difficultly differentiating tumor from inflammation. Imaging choline metabolism with PET can overcome some limitations of FDG PET and has clinical potential in tumors such as prostate cancer, brain tumors and bladder cancer with a significant advantage over FDG PET. The basic principle for imaging choline metabolism with PET, PET tracers for imaging choline metabolism and their applications are summarized.