环丙氟沙星随机对照治疗细菌感染性疾病的临床评价

CLINICAL EVALUATION OF CIPROFLOXACIN IN TREATMENT OF BACTERIAL INFECTIONS DISEASES

本文使用国产环丙氟沙星(0.2g,3次/d或0.4g,2次/d,疗程7～14天)随机对照治疗呼吸道感染12例,泌尿道感染12例,消化道感染6例。结果呼吸道感染总有效10/12,泌尿道感染11/12,消化道感染6/6。各组感染细菌均获清除,包括7株绿脓杆菌感染。体外抗菌研究显示本品对92%以上临床分离菌敏感,对大多数细菌的MIC为0.02～2.5mg/L不良反应少见且轻微。

12 patients with respiratory tract infection,12 with urinary tract infec- tion,and 6 with GI infection were treated with ciprofloxacin(200mg tid or 400mg bid for 7-14 days)with a general response rate of 10/12 for respiratory tract infection,11/12 for urinary tract infection,and 6/6 for GI tract infection.Bacterial eradication are 100% in all the cases including 7 cases of pseudomonas infection.Antibiotic sensitivity test in vitro indicated that 92% of the strains isolated from clinic are susceptible to the drug with MIC ranging 0.02～2.5mg/L