摘要
本实验参照美国药典U.S.P(ⅩⅩⅡ)有关溶出度的测定标准,采用RC-3B药物溶出仪,使用两种不同的溶出介质,选用桨法,以751G紫外分光光度计在270nm处进行检测,对国内外4个厂家4个批号的法莫替丁片进行了体外溶出度测定,其中3个厂家的产品达到了U.S.P规定的标准,30分钟溶出不少于75%.只有1个厂家的法莫替丁片没有达到标准。
Four batches of fomatidine tablets produced domestically and abroad were tested by method described in USP(ⅩⅩⅡ).Using dissolution apparatus of type Rc-3B and UV spectrophotometer type 751G.it was found that three batches of the tablets met the requirements stated in USP,i.e.not less than 75% of the content were dissolved with in 30 minutes,and one batch of the tablet did not met the requirements.
出处
《中国新药杂志》
CAS
CSCD
1992年第2期46-48,59,共4页
Chinese Journal of New Drugs
关键词
法莫替丁
溶出度
Fomatidine
Dissolution
