诺衡和美降脂治疗原发性高胆固醇血症的疗效比较

COMPARISON OF EFFICACY OF GEMFIBROZIL AND LOVASTATIN IN TREATMENT OF PRIMARY HYPERCHOLESTEROLEMIA

91例原发性高胆固醇血症随机分为服诺衡47例和美降脂44例,治疗3个月与治疗前比较,两药降低血清总胆固醇、低密度脂蛋白-胆固醇、载脂蛋白B、TC-HDL·C/HDL·C比值、甘油三酯的作用显著,诺衡升高血清高密度脂蛋白-胆固醇和载脂蛋白A_I作用也明显。两药比较,诺衡比美降脂降低血清甘油三酯和升高血清高密度脂蛋白-胆固醇的作用明显,美降脂降低血清总胆固醇、低密度脂蛋白-胆固醇、TC-HDL·C/HDI·C比值优于诺衡。

91 patients were randomly divided into 2 groups and treated with gemfibrozil and lovastatin respectively and comparisons were made on the results obtained.It was concluded from this study that although both drugs can reduce TC, TG,LDL-C,and the ratio of TC-HDL·C/HDL·C but gemfibrozil was 2 to 3 times as effective as lovastatin in lowering TG,whereas lovastatin was 1.5 to 2 times more effective than gemfibrozil in lowering TC,LDL-C,and the ratio of TC-HDLC/HDL·C. Both of the drugs were well tolerated by the patients.