α-干扰素治疗慢性丙型肝炎研究近况

TREATMENT OF CHRONIC HEPATITIS C WITH ALPHA INTERFERON

Hoofnagle等1986年对慢性丙型肝炎进行治疗试验,结果表明重组α—干扰素有明显效果。此后的多次随机对照试验证实,α-干扰素对慢性丙型肝炎确实有效。试验历24周,每周3次,注射α-干扰素3MU/次,50%以上病人出现完全应答,但停药后约半数病人复发。进一步研究必须着重于长远疗效。

A pilot study conducted by Hoofnagle et al.(1986)showed that the treatment of chronic hapatitis c with recombinant α-interferon(α-2b:Ihtron A,Schering) was markedly effective.The results from this pilot study were encouraging and were support-ed by a number of randomized,controlled trials of α-interferon in patients with chronic hep-atitis C.in a dose of 3 MU 3 times a week for 24 weeks,a definite response to therapy oc-curred in more than 50% of patients,but relapses occurred in about 50% of patients after therapy.The further studies should be directed to the intended parmanent effect.