柳氮磺吡啶栓治疗100例溃疡性结肠炎

THE TREATMENT OF ULCERATIVE COLITIS WITH SASP SUPPOSITORY IN 100 CASES ANALYSIS

国内溃疡性结肠炎(U.C)发病率近年有所增高,疗效尚欠满意。本组100例U.C用自行研制的柳氮磺吡啶(SASP)栓治疗,每粒含SASP 0.5g,治疗量1～1.5g/d,维持量0.5g/d,未发现不良反应。近期治愈率为48%,好转47%,总有效率95%。其疗效与药物直接在结肠内缓慢弥散有关,且直接给药减少了对胃刺激,血浓度低,故无副反应,可做为目前治疗U.C的首选药物。

In recent years,the morbioity of ulcerative colitis(U.C)has been in-creased in China,but the result of general treatment was not satisfactory.We used SASP suppository(made by ourselves)for 100 patients with U.C.Each suppository contains 0.5g of SASP.The dose was 1.5g per day,and maintenance dose 0.5 per day,There were no side effects.The recent recovery rate was 48%,improvement rate 47%,the total effective rate was 95%.This may be related to drug spreading over colon directly and slowly.The admin-istration of drug to colon reduced stomach upset and drug content in serum was lower,so there was no side effect.This study shows that SASP suppository can be chosen firstly totreat U.C