期刊文献+

白细胞介素在溃疡性结肠炎发病机制中的研究进展 被引量:11

原文传递
导出
摘要 近年来,对白细胞介素(IL)在溃疡性结肠炎(UC)肠道炎性反应的主要作用有了较为深入地研究,认为由单核细胞和巨噬细胞产生的炎性细胞因子IL-1、H-8、IL-6、TNF-α等在肠道炎症调控中具重要意义[1].其中炎性抑制因子如IL-1ra、IL-10、IL-4则与炎性细胞因子的作用相抗衡.
作者 李睿 邹开芳
出处 《临床消化病杂志》 2004年第2期88-91,共4页 Chinese Journal of Clinical Gastroenterology
  • 相关文献

参考文献6

二级参考文献25

  • 1安子元.溃疡性结肠炎新的诊断标准[J].新消化病学杂志,1994,2(1):57-57. 被引量:18
  • 2Daig R,Gut,1996年,38卷,216页
  • 3MacDonald TT, Monteleone G, Pender SL. Recent developments in the immunology of inflammatory bowel disease. Scand J Immunol, 2000, 51:
  • 4~9.2.Kitani A, Fuss IJ, Nakamura K, Schwartz OM,Usui T, Strober W. Treatment of experimental(Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor(TGF)-betal plasmid: TGF-betal-mediated suppression of T helper cell type i response occurs by interleukin (IL)-10 induction and IL-12 receptorbeta2 chain downregulation. J Exp Med, 2000,192: 41~52.
  • 5Das KM, Dasgupta A, Mandal A, Geng X. Autoimmunity to cytoskeletal protein tropomyosin. Aclue to the pathogenetic mechanism for ulcerative colitis. J Immunol, 1993, 150: 2487~2493.
  • 6Biancone L, Mandal A, Yang H, Dasgupta T, Paoluzi AO, Marcheggiano A, Paoluzi P, Pallone F,Das KM. Production of immunoglobulin G and G1antibodies to cytoskeletal protein by lamina propria cells in ulcerative colitis. Gastroenterology,1995, 109: 3~12.
  • 7Rogler G, Brand K, Vogl D, Page S, Hofmeister R,Andus T, Knuechel R, Baeuerle PA, ScholmerichJ, Gross V. Nuclear factor kappaB is activated inmacrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology, 1998, 115: 357~369.
  • 8Schreiber S, Nikolaus S, Hampe J. Activation ofnuclear factor kappa B inflammatory bowel disease. Gut, 1998, 42: 477~484.
  • 9Jones SC, Evans SW, Lobo AJ, Ceska M, AxonAT, Whicher JT. Serum interleukin-8 in inflammatory bowel disease. J Gastroenterol Hepatol,1993, 8: 508~512.
  • 10Keshavarzian A, Fusunyan RD, Jacyno M, Winship D, MacDermott RP, Sanderson IR. Increasedinterleukin-8 (IL-8) in rectal dialysate from patients with ulcerative colitis: evidence for a biological role for IL-8 in inflammation of the colon.Am J Gastroenterol, 1999, 94: 704~712.

共引文献121

同被引文献119

引证文献11

二级引证文献66

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部