急性心肌梗塞早期血浆儿茶酚胺及心钠素变化与病情关系的临床探讨

CTION CLINICAL EVALUATION OF CORRELATION BETWEEN PLASMA CATECHOLAMINE, ATRIAL NATRIURETIC PEPTIDE AND CLINICAL CONDITION IN EARLY ACUTE MYOCARDIAL INFAR-

通过对42例急性心肌梗塞(AMI)血浆儿茶酚胺(CA)、心钠素(ANP)及心肌酶变化的研究,发现AMI发病后48h内血浆去甲肾上腺素(NE)及肾上腺素(E)、心钠素(ANP)、血清乳酸脱氢酶(LDH)、硝酸肌酸激酶(CPK)、谷草转氨酶(SGOT)均明显高于对照组,血浆CA及ANP的变化范围与心功能不全的严重度及心肌细胞的破坏程度密切相关。同时我们还发现血浆CA与ANP之间也呈明曼正相关。上述资料提示,AMI患者血浆CA及ANP变化有助于病情严重度的估价。

The changes of plasma concentrations of catecholamine(CA), atrial natriurctic peptido (ANP) and myocardial enzymes were studied in 42 patients with acute myocardial infarction(AMI). The results showed that plasma noradreualine, adrenaline and ANP concentrations, and serum LDH, CPK, SGOT were significantly higher than those of control group within 48 hours after the onset of AMI. The range of variations of plasma CA and ANP was closely related to the severity of heart dysfunction and destruction of myocardial cells. It also showed that the change of plasma CA was closely correlated with that of ANP. Correlative analysis indicated that the higher the plasma CA concentration, the more the plasma ANP and so the release of myocardial enzymes. These data suggest that changes of plasma CA and ANP in cases of AMI could help to evaluate the severity of AMI.