尿激酶静脉溶栓治疗急性心肌梗塞

INTRAVENOUS UROKINASE FOR THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION

本文采用冠脉再通的非创伤性指标,分析90万单位尿激酶快速静脉给药治疗急性心肌梗塞的疗效,再通率为47.62%。在各种非创伤性指标中,再通指数、∑ST下降率、STmax下降率等指标较为敏感。

The effect of rapid intravenous UK administration in 42 cases of acute myocardial infarction was evaluated by noninvasive parameters. The results showed that reperfusion rates were 47.620%and 4.76% (p<0.002), the rates of ΣST decrease by 4hr were 40.68% and 16.17% (p<0.05), the times of reaching peak CPK value were 19.65±5.16 hr and 24.60±8.02 hr (p<0.05), the recanalization indices were 11.28±7.25 and 23.24±16.44 (p<0.05), the incidences of arrhythmia within 4 hr were 42.86% and 33.33% (p>0.05), numbers of cases with disappearance of chest pain within 4 hr were 7 and 0 (p<0.01) in the UK and control group respectively. Three of the 11 cases in recanalization group did not develop Qwave while 31 others all showed Q-wave infarction (p<0.02). Death rate of the recanalization group was 9.09%, while that of the non-recanalization group was 12.90% (p>0.05). No bleeding was found in the UK group. Among the parameters studied, recanalization index, rate of ΣST decrease and rate of STmax decrease were found to be more sensitive than the others.