长效二氢奎尼丁(赛利科)治疗阵发性心房颤动临床观察初步报告

LONG-TERM EFFICACY OF DIHYDROQUINIDINE ON PAROXYSMAL ATRIAL FIBRILLATION

26例服用普罗帕酮、奎尼丁(短效)或氟卡尼无效的阵发性心房颤动或心房扑动患者,口服长效二氢奎尼丁300mg一日2次,平均随访3.8±1.7个月,20例(77%)患者发作次数明显减少或终止发作。无致心律失常等严重副作用。

Long-term efficacy of oral dihydroquinidiue (300mg b.i.d.)was evaluated in 26 (18 males, 8 females, mean age 54±12 years)patients with frequent atrial fibrillation(Af). The frequency of Af was 6±3(4～30)per month before the study. Electrocardiogram, Holter monitoring, Echocardiography and X-ray chest film were performed before and after treatment. After 1 to 6(mean 3.8±1.7) months follow-up, 18(77%) patients were improved significantly including completely control of Af n 10 iand obvious decrease of the attacks(over 90%) of Af in 8. The P-R interval, Q-Tc, ORS and heart rate did not change significantly. Seven (27%)patients experienced diarrhea during the first week of therapy but recovered spontaneously thereafter. No other side effects or new arrhythmias were found. We conclude that dihydroqui- nidine is a safe and effective agent for patients with paroxysmal fibrillation.