卡托普利对心肌梗塞后左室容积和功能的影响

EFFECT OF CAPTOPRIL ON LEFT VENTRICULAR VOLUME AND FUNCTION AFTER MYOCARDIAL INFARCTION

69例心肌梗塞后患者分为卡托普利组(34例)和安慰剂组(35例)。结果:用药前和用药后6、9、12个月二维超声心动图相比较,卡托普利组的左室舒张末期容积指数(LVEDVI)无著变;左室收缩末期容积指数(LVESVI)降低,每搏量指数(SVI)和射血分数(EF)增加(P均<0.05);安慰剂组的LVEDVI和LVESVI增加,EF降低(P均<0.05)。两组间比较。第6个月以后上述指标差异均显著(P<0.01)。

Sixty-nine patients 4～5 weeks after acute myocardial infarction with ejection fraction<45% were randomly divided into placebo (n=35) and captopril (n=34, 12.5mg t.i.d.) groups. Left ventricular end-systolic volume index (LVESVI). left ventricular end-diastolic volume index (LVEDVI), stroke volume indcx(SVI)and ejection fraction (EF) were measured at baseline and 1,3,6,9 and 12 months after treatment with cross-sectional echocardiography and Simpsons rule analysis of standardized apical views. The captopril group showed no significant change in LVEDVI but significantly reduced LVESVI and significantly increased SVIEF from the 6th month on. In contrast, placebo group showed significant increase in LVEDVI with unchanged SVI and reduced EF (p<0.05). Significant differences were found in the captopril group in comparing with the placebo group (p<0.01) from the 6th month on.The results indicate that after myocardialinfarction ventricular enlargement is progressive and that ACE-I attenuates this process and improves cardiac function.