急性心肌梗塞患者血浆Ⅷ因子相关抗原的动态观察

DYNAMIC CHANGES OF PLASMA VON WILLEBRAND FACTOR (vWF) ACTIVITY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

为探讨急性心肌梗塞(AMI)与Ⅷ因子相关抗原(vWF)的关系,我们动态观察61例AMI发病第1、3、7、14、21天五个时间组vWF的变化。结果表明,AMI各时间组血浆vWF均较正常组高(P<0.01),第3天最高,1周后逐渐下降,AMI第1、3、7天组分别与第14、21天组比较,差异显著(P<0.05)或非常显著(P<0.001),死亡组较存活组高,但差异无显著性(P>0.01)。通过观察认为血浆vWF的变化与AMI临床病情的关系值得进一步探讨。

Serial activities of plasma vwF of 61 patients with myocardial infarction were measured in the 1st, 3rd, 7th, 14th and 21th day after onset and compared with normal controls. The results showed that the activities of plasma vWF in AMI group were increased apparently within 7 days and the peak was found at the 3rd day after onset and decreased steadily from the first week on. The activities of plasma vWF in AMI were higher in the dead cases than those in the survivals. There was no significant difference in the activity of plasma vWF between AMI with and without complications. The conclusion shows that it is worth further survey of the value of measuring plasma vWF for the prediction of the severity and pro gnosis of AMI.