摘要
本文建立大鼠肺动脉高压模型,并用川芎嗪和青霉胺进行预防用药。结果表明,二种药物均能缓解肺动脉高压和右心室肥大。
The effects of ligustrazine (Lig) and penicillamine(Pen) on the hemodynamics and structural changes of heart and lung of male SD rats when exposed tO normobaric hypoxia-hypercapnia were studied. The results showed that both drugs lowered pulmonary arterial hypertension(PAH), attenuated pulmonary small vessel muscularization and right ventricu]ar hypertrophy, suggesting that both Lig and Pen have preventive effects on experimental pulmonary hypertension.
出处
《中国循环杂志》
CSCD
1992年第6期576-578,共3页
Chinese Circulation Journal
基金
国家"七五"科技攻关课题
关键词
肺动脉高压
川芎嗪
青霉胺
Pulmonary hypertension
Ligustra- zine
Penicillamine
