薏苡仁注射液联合低剂量顺铂和5-氟尿嘧啶治疗晚期胰腺癌的临床观察

Treatment of pancreatic cancer of late stage by use of Kang-Lai-Te and small dosage cisplatin,5-fluorouracil

目的 本文观察了薏苡仁注射液 (康莱特、KLT)联合低剂量顺铂 (DDP)和 5 氟尿嘧啶 (5 FU)联合方案治疗晚期胰腺癌的疗效及毒副作用。方法 化疗方案康莱特 10 0ml静滴 ,d1～d2 0 ,间隔 8天 ,5 FU 32 0mg/ (m2 ·d) ,持续 8h ,连用 2周 ,DDP5mg/ (m2 ·d)每周 5天连用 2周 ,其后休息 2周 ,连用两个周期后进行疗效评价。结果 12例晚期胰腺癌中PR 2例 ,SD 7例 ,PD 3例 ,总有效率 16 .6 7%。 7例疼痛减轻、行为状况评分提高或体重增加 ,临床受益反应率为 5 8.33%。治疗后NK、CD 3、CD 4和CD 4 /CD 8值较治疗前有明显提高。主要毒副作用为轻度的血液和消化道副反应。结论 康莱特联合低剂量DP和5 FU联合化疗方案对晚期胰腺癌能够提高缓解率和临床受益反应率 ,毒副反应能耐受。

Objective To evaluate effectiveness and side effect in the treatment of pancreatic cancer with Kang-lai-te and small dosage of cisplatin,5-fluorouracil. Methods It is estimated the effect after treated two cycles;the chemotherapy plans was kang-lai-te 100 ml ivgtt (d1～d20),after eight days continue. 5-fluorouracil 320 mg/(m 2 ·d),8 hours continonusly,2 weeks and small dosage cisplatin 5 mg/(m 2 ·d),5 times per week,2 weeks,having 2 weeks for rest. Results 12 cases of pancreatic cancer were treated;the effect rate was 16.67% .PR 2 cases,SD 7 cases,PD 5 cases. Clinical benefit response 58.33%.and after treatment had improved NK、CD 3 、CD 4 and CD 4 /CD 8 . With the mild bad affect in blood and gastro-intestine. Conclusion It is a effective strategy in pancreatic cancer the treatment of to use kang-lai-te and small dosage cisplatin,5-fluorouracil. Clinical benefit response is high. The bad affect seems supportable.