发作性睡病及其药物治疗被引量：4

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摘要发作性睡病临床上表现为病理性睡眠、猝倒症、睡瘫症和入睡性幻觉四联症,系由于异常快眼动相睡眠所致。发病与遗传和环境因素有关,食欲素与发作性睡病的关系令人注目。治疗包括精神兴奋剂和抗抑郁剂等,其中莫达非尼倍受青睐。

作者王文昭邵福源

机构地区第二军医大学附属长征医院神经内科

出处《世界临床药物》 CAS 2004年第4期203-207,共5页 World Clinical Drug

关键词发作性睡病药物疗法临床表现病理性睡眠猝倒症睡瘫症入睡性幻觉

参考文献10

1Silber MH,Krahn LE,Olson EJ.Diagnosing narcolepsy: validity and reliability of new diag nostic criteria[].Sleep Medicine Reviews.2002
2Lecendreux M,Maret S,Bassetti C,et al.Clini cal efficacy of high-dose intravenous immuno globulins near the onset of narcolepsy in a 10 year-old boy[].Journal of Sleep Research.2003
3Dauvilliers Y,Carlander B,Molinari N,et al.Month of birth as a risk factor for narcolepsy[].Sleep.2003
4Boivin DB,Montplaisir J.The effects of L-dopa on excessive daytime sleepiness in narcolepsy[].Neurology.1991
5Scharf MB,Lai AA,Branigan B,et al.Pharma cokinetics of gammahydroxybutyrate (GHB) in narcoleptic patients[].Sleep.1998
6Tafti M,Dauvilliers Y.Pharmacogenomics in the treatment of narcolepsy[].Pharmacogenomics.2003
7Fujiki N,Yoshida Y,Ripley B,et al.Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin ligand-deficient narcoleptic dog[].Sleep.2003
8Korotkova TM,Sergeeva OA,Eriksson KS,et al.Excitation of ventral tegmental area dopaminer gic and nondopaminergic neurons by orexins/ hypocretins[].The Journal of Neuroscience.2003
9Dauvilliers Y,Baumann CR,Carlander B,et al.CSF hypocretin-1 levels in narcolepsy, Kleine Levin syndrome, and other hypersomnias and neurological conditions[].Journal of Neurology Neurosurgery and Psychiatry.2003
10Chabas D,Taheri S,Renier C.The genetics of narcolepsy[].Annual Review of Genomics and Human Genetics.2003

1王淑惠,葛盛秋.民用航空医学进展──美国航空航天医学会第65届年会论文简介[J].中华航空医学杂志,1994,5(4X):242-245. 被引量：2
2苑隆国,李电东.新型中枢兴奋药莫达非尼[J].中国新药杂志,2006,15(2):149-151. 被引量：12
3Overeem S, Mignot E, et al. Narcolepsy Clinical features new pathophysiologic inSights and future perspectives [J]. J Clin Nerurophy Siol,2001,18(2) :78-105.
4Westcott K J.Modafinil,sleep deprivation,and cognitive function in military and medical settings[J].Mil Med,2005,170(4):333-335.
5Fry J M.Treatment modalitles for narcolepsy[J].Neurology,1998,50(Suppl 1):S43-S48.
6Schwertner H A,Kong S B.Determination of modafinil in plasma and urine by reversed phase high-performance liquid-chromatography[J].J Pharm Biomed Anal,2005,37(3):475-479.
7LAB L, LAFON SA (FRANCE). Modafinil [ J ]. Drugs Future,1990,15(1) :130.
8ENGBER TM, DENNIS SA, JONES BE, et al. Brain regional substrates for the actions of the novel wake-promoting agent modafinil in the rat: comparison with amphetamine[J] . Neuroscience, 1998, 87(4):905-911.
9L1N JS, HOU Y, JOUVER M. Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidence by c-fos immunocytochemistry in the cat[J]. Proc NatI Acad Sci USA , 1996,93(24) :14128-14133.
10HOU YP, LIN ,IS. Effects of modafinil and amphetamine on sleep-wake cycle after sleep deprivation in cats[ J ]. Aeta Pharmacol Sin, 1999,20(9) :813 - 818.

1苑隆国,李电东.新型中枢兴奋药莫达非尼[J].中国新药杂志,2006,15(2):149-151. 被引量：12
2雷志坚,梁碧芳,刘建红,刘航,王武.多次小睡试验和受试者的护理干预[J].护士进修杂志,2009,24(12):1137-1139.
3颜鸣,马宏达,郭涛.莫达非尼肠溶片体外释放度的研究[J].药学服务与研究,2009,9(3):227-229. 被引量：2
4张婷婷,康维礼,叶春生,郭沈昌.抗抑郁药和胞磷胆碱合并治疗发作性睡病的疗效观察[J].中华临床医师杂志（电子版）,2013,7(20):136-136. 被引量：2

世界临床药物

2004年第4期

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