摘要
目的 :观察脂脉舒与辛伐他汀合用对高脂血症的治疗效果。方法 :用家兔制作高脂血症模型 ,分辛伐他汀组和脂脉舒加辛伐他汀组进行治疗 ,观察用药前后血脂和血糖及肝、肾功能等指标的变化。结果 :辛伐他汀、脂脉舒加辛伐他汀均能明显降低血中总胆固醇、甘油三酯、低密度脂蛋白胆固醇的含量 ;而脂脉舒加辛伐他汀联用还能明显升高高密度脂蛋白胆固醇含量 ,并能抑制血糖和丙氨酸转氨酶水平的升高。脂脉舒合用辛伐他汀组的尿酸和肌酐水平均低于对照组和单用辛伐他汀组。结论 :将脂脉舒与辛伐他汀合用能整体地、多方面地调节高脂血症的代谢紊乱 ,减轻单用他汀类药物引起的肝脏损害。
Objective: To observe the treatment effect of combining simavastatin with Zhimaishu(脂脉舒) for hyperlipidemia. Methods: The models of hyperlipidemia were made on the rabbits and were randomly divided into the simavastatin group and the combining simavastatin with Zhimaishu group. Two groups were administered the drugs respectively. The blood indexes (lipids and glucose etc.) were detected before trial and after administration. Results: Both simavastatin and combining simavastatim with Zhimaishu could obviously decrease total cholesterol, triglycerides and low-density lipoprotein cholesterol(LDLC) levels. But combining simavastatin with Zhimaishu treatment could obviously increase high-density lipoprotein cholesterol(HDLC) content and inhibit the increase of blood glucose and alanine transaminase(ALT), and the levels of uric acid and creatinine were lower compared to those of control and simavastatin treatment along. Conclusion: The combining simavastatin with Zhimaishu basically may adjust the lipodystrophia as a whole.
出处
《中国中西医结合急救杂志》
CAS
2004年第2期107-109,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
广东省中医药管理局立项课题 ( 4 0 10 45 )
