肺部疾病患者血浆D-二聚体测定的临床意义

Clinical Significance of D-dimer Serum Concentration in the Development of Pulmonary Disease

目的 探讨凝血系统激活在肺部疾病发生发展中的作用及临床意义。方法 对 2 0 0 1年 5月至 2 0 0 2年 12月在我院呼吸科住院的肺部疾病患者血浆 D-二聚体浓度进行检测。结果 肺心病急重期和缓解期患者血浆D-二聚体浓度与对照组比较 ,差别有非常显著性意义 (x2 =34.89,P<0 .0 1) ,急重期与缓解期比较差异有显著性(P<0 .0 5 ) ,与肺结核组比较差异有显著性 (P<0 .0 5 )。肺小细胞癌及非小细胞癌患者 D-二聚体浓度与对照组比较差异有显著性 (P<0 .0 1) ,与肺结核患者比较差异无显著性 (P>0 .0 5 )。肺结核进展期与好转期患者血浆 D-二聚体浓度与对照组比较差异无显著性 (P>0 .0 5 )。结论 D-二聚体浓度检测对肺部疾病的诊断、预后及疗效判定有临床应用价值。

Objective To explore the functions and significance of activation about zymoplastic system in the development of pulmonary disease.Methods Serum concentration of D-dimer were measured with 95 inpatients admitted between May 2001 and December 2002 who had either cor pulmonale, lung cancer, or tuberculosis. Statistical comparisons were made. Results Serum concentration of D-dimer was significantly higher in patients in cor pulmonale group than that in the control group (x 2=34.89, P<0.01). Serum concentration was higher in patients at acute aggravating stage than that at stable stage for cor pulmonale group (P<0.05). They were higher in tuberculosis group than those in controls (P<0.05). Serum concentration of D-dimer was significantly higher in patients with NSCLC and SCLC than that in the control group (P<0.01). There was no significant difference between lung cancer and tuberculosis groups (P>0.05). There was no significant difference between tuberculosis group and control group at stable and improvement stages (P>0.05).Conclusion The examination of D-dimer has favorable clinical prospect for the diagnosis, prognosis and the treatment for the lung diseases.