BiPAP呼吸机治疗COPD急性呼吸衰竭的疗效

The Treatment Effects of BiPAP on Chronic Obstructive Pulmonary Disease Patients with Acute Respiratory Failure

目的 探讨 (鼻 )面罩双水平气道正压通气 (Bi PAP)治疗在慢性阻塞性肺部疾病 (COPD)急性呼吸衰竭的治疗作用。方法 5 2例 COPD急性加重合并呼吸衰竭患者应用 Bi PAP呼吸机辅助通气治疗 ,记录通气治疗前及通气治疗 2 h、2 4 h条件下患者的血气分析及第一秒用力肺活量 (FEV1 )、用力肺活量 (FVC)。结果 治疗前二氧化碳分压 (Pa CO2 ) (76± 15 ) mm Hg,肺功能 FVC(1.2 8± 0 .2 0 ) L ;治疗后 Pa CO2 (4 0± 9) mm Hg,FVC(1.32± 0 .2 0 )L,二者无显著性差异 (P>0 .0 5 )。而治疗前动脉血氧分压 (Pa O2 ) (4 8± 12 ) mm Hg,FEV1 (0 .6 7± 0 .0 7) L,治疗后Pa O2 (88± 16 ) mm Hg,FEV1 (0 .85± 0 .2 0 ) L,二者有显著差异 (P<0 .0 5 )。结论 应用 Bi PAP呼吸机辅助通气治疗COPD急性呼吸衰竭可提高 Pa O2 ,降低 Pa CO2 ,改善肺功能。

Objective To study the effects of bilevel positive airway pressure (BiPAP) on acute respiratory failure in chronic obstructive pulmonary disease (COPD) patients.Methods 52 COPD patients with acute respiratory failure were treated by BiPAP. Records of the lung functions and blood air index were made before and after the ventilation. Results Before and after the therapy, the difference of arterial carbon dioxide tension and lung function FVC was not significant (P>0.05) but arterial oxygen tension and FEV1 increased significantly (P< 0.05).Conclusion Using BiPAP respiratory machine assistant ventilation can heighten arterial oxygen tension, lower PaCO 2, improve lung function in the treatment of COPD patients who have acute respiratory failure.