组织培养川贝母化学成分和药理作用的研究

Research on Chemical Components and Primary Pharmaceutical Actions of Cultured Bulb of Fritillaria Unibracteata

贝母为常用中药之一,味苦、性寒,有清热润肺,化痰止咳、散结等功能,用于痰热咳嗽、咯痰带血,瘰疬疮疡肿毒。国内入药主要是川贝、浙贝、平贝和伊贝。《本草纲目拾遗》

Qualitative and quantitative analysis of alkaloids in cultured bulb of Fritillaria unibracteata were made respectively by TLC and acid dye colormetry as compared with that in wild bulb. The content of microelements in cultured bulb also be determined. The results obtained indicated that the types of alkaloids in cultured bulb were similar to that in wild bulb, the contents of alkaloid and beneficial microelements in cultured bulb were higher than that in wild bulb, but harmful microelements were lower in cultured bulb. Furthermore, the actions of relieving cough and cleaning away phlegm of cultured bulb were compared with that of wild bulb. The results of primary pharmaceutical experiments showed that both bulbs have similar effects of relieving cough and cleaning away phlegm on mice. It is possible to use cultured bulb as a substitute for wild bulb for medicinal uses.