阿尔茨海默病与血管性痴呆胼胝体的体视学定量研究

A quantitative study of corpus callosum in patients with Alzheimer's disease and vascular dementia with stereology

目的:运用体视学知识对胼胝体体积的定量测量,以探讨胼胝体萎缩与阿尔茨海默病(Alzheimer'sdisease,AD)、血管性痴呆(vasculardementia,VD)的关系。方法:AD组、VD组、对照组各20例,应用T1加权成像序列,矢状面扫描,层厚1cm,无间断,通过体视学知识对矢状面胼胝体体积、颅腔体积进行测量,并对胼胝体体积进行标准化。结果:AD组、VD组相比,胼胝体体积犤(21.15±1.53),(21.55±1.82)cm3犦及标准化体积(14.25±0.66,14.53±1.12)差异无显著性意义(P=0.487,0.311)但两组均小于正常组(P<0.01)。结论:AD与VD患者胼胝体均显著性萎缩,提示AD,VD患者可能存在着左右大脑半球沟通的异常,但这不能作为AD,VD患者鉴别的依据。

AIM:To quantitatively measure the volume of corpus callosum in the patients with Alzheimer's disease(AD) and vascular dementia(VD) by using stereology so as to investigate the relationship of corpus callosum atrophy with AD and VD. METHODS:There were 20 patients respectively in AD group,VD group and normal control group.Craniocerebral scanning at 1 cm thickness was continuously performed in the three groups with sagittal T1 weighted magnetic resonance imaging sequence. Quantitative measurements were made with stereology,including volume of cranial cavity and sagittal corpus callosum.Then corpus callosum volume was standardized. RESULTS:There were no significant differences between the AD and VD groups in the volume of corpus callosum[(21.15±1.53) vs(21.55±1.82) cm3,P=0.487]and the standard volume[(14.25±0.66) vs(14.53±1.12) cm3,P=0.311].However, the values of the two groups were both smaller than those of the control group(P< 0.01). CONCLUSION:Atrophy of corpus callosum is apparent in the patients with AD and VD,indicating there is a obstacle in the communication between the two hemispheres of the patients with AD or VD, but it cannot be used for the differentiation of AD or VD patients.