摘要
本文报道了化合物E-(1-羟基-2,2-二甲基-6-苯亚甲基-3,3-亚乙二氧基环己基)乙酸(12)的合成路线。并以2,2-二甲基-1,3-环己酮为起始原料,经过单缩酮化、羟醛缩合、Reformatsky反应,酯水解四步反应制得目的物,总收率为13.9%。
The route of synthesizing E-(3,3-ethylenedioxy-1-hydroxy-2,2-dimethyl-6-phenylmethylene) cyclohexy-laceticacid (12) was designed. This compound, which was obtained from 2, 2-dimethyl-1, 3-cyclohexanedione via monoketalization, condensation with benzaldehyde, Reformatsky reaction and hydrolysis, is an important intermediate for the synthesis of derivative (3) of taxamairin B.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1992年第2期71-73,共3页
Journal of China Pharmaceutical University
基金
国家自然科学基金
关键词
红豆杉素B
环已烷乙酸
单缩酮化
Taxamairin B
Cyclohexylacetic acid
Monoketalization
Reformatsky reaction
