摘要
林可霉素的C-7(R)-OH经氯代反应后可得C-7(S)-Cl化合物,即克林霉素(Clindamycin)。
A new method for the chlorination of lincomycin is described. Lincomycin was chlorinated by Vilsmeier-Haack Reagent instead of by Rydon Reagent. Clindamycin obtained from this method was improved both in its quality and yield.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1992年第4期248-249,共2页
Journal of China Pharmaceutical University
关键词
林可霉素
氯代
克林霉素
Lincomycin
Chlorination
Clindamycin
Vilsmeier-Haack Reagent
