笔管草醇提物的调节血脂作用

The Modifying Effect on Hyperlipidemia by the Extraction of Equisetum Debile Roxb

目的 观察笔管草醇提物对正常大鼠及实验性高脂血症兔的降脂作用。方法 用不同剂量的笔管草醇提物给予大鼠灌胃 (ig)给药 ,1次 /d ,连续 15天 ,测大鼠血清中甘油三脂 (TG)和总胆固醇(TC)浓度 ;另将笔管草醇提物加在高脂兔饲料中加工成含有不同药物浓度的兔饲料 ,按每天 10 0 g/只 ,连续喂养 6 0d ,观察其对家兔血清中TG、TC和 β-载脂蛋白浓度的影响。 结果 不同剂量的笔管草醇提物能降低大鼠血清中TG和TC浓度 (P <0 .0 5 ) ,对实验性高脂血症兔能降低血中TC浓度 (P <0 .0 5 ) ,而对TG和 β -载脂蛋白无明显影响(P>0 .0 5 )。结论 笔管草醇提物具有良好的调节血脂作用。

Objective To observe the effects on the triglyceride and cholesterol of normal rats and the rabbits of hyperlipidemia by the Equisetum Debile Roxb extraction by alcohol Methods Rats were given various doses Equisetum Debile Roxb extraction by alcohol (ig) intragastricly for 15 days. Then the triglyceride and total cholesterol of blood were measured. Every rabbit was given fodder (100 g/day) for 60 days. The fodder was contained some cholesterol and oil added with various dose of Equisetum Defile Roxb extraction by alcohol. Then the triglyceride and total cholesterol and the b-apoprotein of blood were measured. Their body weigh was measured. Results Equisetum Debile Roxb extraction by alcohol could decrease the triglyceride and total cholesterol of rat (P<0.05) and triglyceride.of the rabbits (P< 0.05). But the concentration of b-apoprotein was not influenced. The body weighs of rats and rabbits did not change greatly. Conclusions Equisetum Debile Roxb extraction by alcohol have regulated blood lipid of normal rat and triglyceride of rabbits significantly.,but the body weight does not change greatly.