充血性心衰患者TNF和CGRP含量及意义

The Change and the significance of tumor necrosis factor and calcitonin gene related peptide in elderly patients with congestive heart failure

目的 探讨老年不同心功能患者肿瘤坏死因子 (TNF)和降钙素基因相关肽 (CGRP)的变化及意义。 方法 用放免法测定 40例充血性心力衰竭 (CHF)组患者血浆TNF和CGRP并与正常对照组 2 0例比较。 结果 CHF组TNF明显高于对照组 (P <0 0 1) ,而CGRP明显低于对照组 (P <0 0 1) ,心衰严重程度与血浆TNF和CGRP水平相关 ,心衰患者TNF与CGRP水平之间呈负相关 (r =-0 82 1,P <0 0 1)。 结论 TNF和CGRP参与心衰的发生和发展 ,测定CHF患者血浆TNF与CGRP可作为判断病情的一个指标。

Objective To investigate the change and the significance of tumor necrosis factor(TNF) and calcitonin gene related peptide(CGRP) in elderly patients with congestive heart failure(CHF). Methods TNF and CGRP levels were determined in 40 patients with CHF by radioimmunoassay and the results were campared with those in normal control group. Results In the heart failure group,TNF level was higher and CGRP level lower than those in normal control group( P <0.01).The plasma level of TNF and CGRP were closely related with the degree of CHF.A negative correlation was showed between TNF and CGRP in CHF group( r =-0.821, P <0.01). Conclusions TNF and CGRP may play an important role in the pathogenesis of CHF.It might be one prognostic marker for CHF patients.