摘要
采用小鼠胸腺细胞增殖法观察了褪黑素(MT)及松果腺培养上清对PMФ产生IL-1的影响。结果表明,MT对MФ产生IL-1无直接影响,但MT(0.1～1μmol/L)可促进脂多糖(LPS)诱导大鼠PMФIL-1的产生。松果腺不同时间培养上清(30,60,120min)对LPS诱导PMФIL-1的产生均有不同程度的促进作用,其中以60min培养上清作用最强(1/45),可能与MT含量多少有关。本研究结果提示,LPS激活的MФ可能是MT作用的靶细胞之一。
Effects of melatonin ( MT ) and supernatants from cultured pineal glands stimulated by 10 μmol/L isoproterenol (ISO) for 0, 30, 60, 120 min on interleukin I ( IL-1 ) production by peritoneal macrophage ( PMφ ) in rats were studied. Theses results showed that LPS-induced IL-1 production by PMφ was enhanced by in vitro treatment with MT (0.1~1 μmol/L ) , but IL-1 production was not influenced by MT without LPS. LPS-induced IL-1 production by PMφ was enhanced in various degree by the supernatants, action of supernatants for 60min was best. The data is suggested that LPS-activated Mφs may be one of target cells for MT.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第1期66-68,共3页
Chinese Pharmacological Bulletin
