摘要
用蔗糖—间隙法研究了Cu^(2+)对离休兔颈上交感神经节的作用。Cu^(2+)对神经节动作电位产生浓度依赖性抑制作用,IC_(50)为0.26mmol/L。其抑制作中在高Ca^(2+)溶液中减弱,在低Ca^(2+)溶液中加强。新斯的明、L—半胱氨酸能拮抗Cu^(2+)的作用。Cu^(2+)对神经节N波和P波有不同程度的抑制作用。对LN波无明显影响。
The effects of Cu2+ on superior cervical sympathetic ganglion of rabbits were studied by the sucrose-gap method. Cu2+ at cumula- tive concentration inhibited ganglion action potentials. IC50 of Cu2+ was 0.26 mmol/L. The effects of Cu2+ were antagonized by neostig-miae and L-cystein, while enhanced under 1/2[Ca2+] and reduced under 3[Ca2+] .Cu2+ inhibited ganglionic N wave and P wave,without affecting LN wave.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第1期24-27,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目
关键词
铜
交感神经节
动作电位
Cu^(2+)
Sympathetic ganglia
Action potentials
Neostigmine
L-cystein
Sucrose-gap method
