硝苯吡啶、阿斯匹林及两者并用对大鼠急性心肌缺血的保护作用

THE PROTECTIVE EFFECTS OF NIFEDIPINE, ASPIRIN AND NIFEDIPINE COMBINED WITH ASPIRIN ON ACUTE MYOCARDIAL ISCHEMIA INDUCED BY PITUITRIN IN RATS

应用垂体后叶素所致大鼠急性心肌缺血模型观察了硝苯吡啶、阿斯匹林及两者并用抗心肌缺血作用。结果表明:20%乙醇(2 ml/kg)、硝苯吡啶(0.05mg/kg)、阿斯匹林(0.025mg/kg)对大鼠缺血性心电图各项指标均无明显影响。硝苯吡啶(0.1mg/kg)、阿斯匹林(0.05mg/kg)及阿斯匹林加硝苯吡啶(o.o25+o.05mg/kg)均能显著对抗垂体后叶素引起的大鼠心电图1、2期ST—T的改变、心率减慢及心律失常的发生。剂量与效应相关。两者并用呈明显的协同效应。

The protective effects of Nifedipine, Aspirin and Aspirin combined with Nifedipine on acute myocardial ischemia induced by pi-tuitrin in rats were studied, when 20% Alcohol (2ml/kg), Nifedipine (0.05 mg/kg) and Aspirin (0.025mg/kg) was singly used, no remakable effects were observed on the indexes of ischemic ECG of the experimental rats. When Nifedipine (0.1mg/kg) or Aspirin (0.05mg/kg) was used singly, or they were used in combination (0.05 + 0.025mg/kg ); The significant counteractions were observed on the changes in ST segments and T waves in the first and second phases of the rats ECG caused by pituitrin, and the occurrence of decrease of heart rate and arrhythmia were prevented. The doses were correlated with the effects. The two drugs used in combination showed noticeable synergism.