酰胺咪嗪的浓度及抗癫痫治疗中毒副反应的研究

STUDIES OF CARBAMAZEPINE CONCENTRATION AND TOXIC AND SIDE REACTIONS IN ANTIEPILEPTIC THERAPY

研究60例口服酰胺咪嗪的癫痫患者血药、唾药浓度及毒副反应的发生率。最适血清浓度为17～38μmol/L,唾药浓度为4～13μmol/L。血药浓度与毒副反应密切相关,CBZ在发挥治疗作用时出现不同程度的毒副反应,随浓度增加发生人次上升。血药浓度超过38～51μmol/L,唾药浓度超过14.8～17μmol/L,毒副反应明显增加。

Carbamazepine ( CBZ ) serum and salivary concentration and toxic and side reactions were studied in 60 epilepsy patients. The propriate CBZ serum concentration was l7~38μmol/L, salivary concentration was 4~13μmol/L. The toxic and side reactions were correlated with serum level, there were different toxic symptoms when CBZ levels were in therapeutic range. When CBZ serum concen tration was higher than 38~51 μmol/L, salivary concentration was higher than 14.8~17 μmol/L, the toxic and side reactions were significant increased in our test patients.