期刊文献+

硒对大鼠钴心肌病的保护作用 被引量:1

PROTECTION OF EXPERIMENTAL COBALT CARDIOMYOPATHY IN RATS BY SELENIUM SUPPLEMENT
下载PDF
导出
摘要 用氯化钴(Co5 m g/kg·d^(-1)×7 ip)引起大鼠钴心肌病,探讨硒的保护作用。预先给硒(Se50μg/kg·d^(-1)×14iP)可防止钴所致心肌损害,表现为血浆CPK和GOT活性下降以及心肌不出现组织病理学改变。给硒可提高心肌硒水平和谷胱甘肽过氧化物酶活性,但对心肌脂质过氧化物含量无影响。与钴组大鼠相比,硒加钴组大鼠心肌琥珀酸脱氢酶(SDH)染色反应增强、脂质染色和游离脂肪酸水平降至正常,说明硒的保护作用机理可能在于:防止钴所致心肌SDH活性的抑制和脂代谢障碍。 The protective effect of selenium ( Se ) on cobalt cardiomyopathy was investigated in rats given cobalt chloride ( 5 mg/kg·d-1×7 i.p.). Pretreatment of Se (50 μg/kg·d-1 ×14 i.p.) could protect the myocardium injured by Co as demonstrated by the decrease in plasma CPK and GOT activities and absence of histopathologic abnormalities. Se contents in hearts and the cardiac glutathione peroxidase activity were increased, but the level of lipid peroxide in the heart was unaltered after i.p. Se. As compared with the Co group rats, SDH reaction was increased in intensity, lipid staining and free fatty acid contents in myocardium of the Se + Co group were decreased to the normal extent, indicating that the protective effect of Se appeared to be related to the prevention of the cobalt-induced inhibition of SDH and disturbance of lipid metabolism in the heart.
出处 《中国药理学通报》 CAS CSCD 北大核心 1992年第2期135-138,共4页 Chinese Pharmacological Bulletin
关键词 保护作用 心肌病 Cardiomyopathy Selenium Protection
  • 引文网络
  • 相关文献

同被引文献6

引证文献1

;
使用帮助 返回顶部