国产血管紧张素Ⅱ与进口产品部分药理活性的比较

A Comparison of some bioactivitiex of A Ⅱ made in China and oversedas

从受体、组织和整体水平着手,对国产血管紧张素Ⅱ(AⅡ)和进口AⅡ的部分药理特性进行了比较研究,实验表明:(1)两种样品在大鼠主X动脉螺旋条和离体豚鼠胆囊平滑肌,所引起收缩的量—效曲线及EC_(50)差异均无显著性(P>0.05);(2)两种AⅡ样品引起大鼠血压升高的ED_(50)差异无显著性(P>0.05);(3)两种AⅡ均能明显抑制^(125)—ⅠAⅡ与膜受体结合,并随浓度增大抑制率增高,两者的量—效曲线几乎重叠,国产AⅡ与进口AⅡ的IC_(50)分别为2.1×10^(-4)mol·L^(-1)和2.0×10^(-8)mol·L^(-1)差异无显著性。以上结果证明,国产AⅡ与进口AⅡ的生物学性质柏同,完全可代替进口AⅡ应用于药理研究中。

The bioactive identity of A Ⅱ made in China and overseas was demonstrated in different levers including receptor, organ and whole body in this report. Therefore, the A Ⅱ made in China can be used in various pharmacological researches in stead of imports.