山莨菪碱对脑缺血局部血流量的影响

The influence of anisodamine on the cerebral blood flow in uncompletely ischemic rat brains

用放射性生物微球法,观察了山莨菪碱对双侧颈总动脉结扎(BCAL)后大鼠脑局部血流量的影响.BCAL使大鼠大脑半球血流量显著减少,以中部最明显。山莨菪减10mg·kg^(-1)iv明显增加缺血最严重的大脑中部血流量,20mg·kg^(-1)iv明显增加整个大脑半球血流量,40mg·kg^(-1)iv则作用减弱。BCAL后心肌血流量明显增加,山莨菪碱20mg·kg^(-1)iv使其进一步增加,但40mg·kg_(-1)iv则使其显著减少。10～20·mg·kg^(-1)iv对BCA L后的心指数无明显影响,40mg·kg^(-1)iV则使其明显增大。

The influence of anisodamine on the cerebral blood flow in the uncompletely ischemic brains was studied with radioactive biomicrosphere assay. After the bilateral carotid arteries were occluded the cerebral blood flow drawmatically decreased and middle part of the hemisphere had the most severe reduction. Anisodamine 10mg · kg-1 iv selectively increased the cerebral blood flow in this area and 20mg · kg-1 increased that in the whole hemisphere. When it was used in the dose of 40mg · kg-, the increasing effect on the cerebral blood flow became weaker. While the cerebral blood flow decreased, the myocardial blood flow increased significantly after bilateral carotid artery occlusion. Anisodamine 20mg · kg-1 iv made it further increase and 40mg · kg-1 iv made it decrease. The cardiac index was not influenced by bilateral carotid artery occlusion and anisodamine 10~20mg · kg-1 iv, but was significanntly increased by anisodamine 40mg · kg-1 iv. These results suggested that anisodamine may be used in the treatment of ischemic cerebral diseases and should be used in different doses according to different purposes.