超声心动图评价负荷量国产氨吡酮对心力衰竭病人左心功能的影响

Effects of load-dose Amrinone on left ventricular function in heart failure patients evaluated by echocardiography

本文用M型和脉冲多普勒超声心动图观察了30例心力衰竭病人静注国产氨吡酮对左心功能的影响.所有受检者氨吡酮(lmg·kg^(-1))iv过程中和用药后10min时所测的左心收缩和舒张功能均较用药前明显改善.每搏输出量增加了20％和18％;心排血量和心脏指数分别增加了23％、19％、和23％、23％;射血分数增加了32％和30％;平均周径纤维缩短率增加了50％和48％;左室舒张早期充盈速度增加了30％和21％.以上各项指标在用药中与用药后差异均无显著性,但两者与用药前差异均有显著性(p<0.05～0.001).用药中和用药后心率有轻度变化.但p>0.05 。

The effects of Amrinone (AMR)on left ventricular function in 30 cases of congestive heart failure patients was assessed by M-mode and pulsed Doppler echocardiography. AMR improves the systolic and diastolic function of left ventricle during and after 10 min (AMR lmg · kg-1, infusion ). The mean stroke volume increased 20% and 18% ; cardiac output increased 23% , 19% ; cardiac index increased 23% and 23% ; ejection fraction increased 32% , 30%; mVcf increased 50% and 48% ; filling velocity in early diastole increased 30% and 21 %; respectively. There were no significant differently between during and after AMR infusion, but there were signifcantly difference a-mong before, during and after AMR infusion. The heart rate changed slightly without statistic significance. The results suggest that AMR could improve the systolic and diastolic function of left ventricle in congestive heart failure patients.