摘要
PVN微注射TRH明显增强胃运动幅度和增快胃相性收缩频率。微注射前胃运动频率为3～4次·min^(-1)胃内压为0.49±0.04kPa,微注射后胃运动频率为6～8次·min^(-1)、胃内压为l.91±0.5kPa。变化持续时间为70～90min,P<0.001。肌肉注射心得安.酚妥拉明均不能改变TRH的作用。迷走神经切断和肌肉注射阿托品能阻断TRH对胃运动的中枢调节作用.本实验结果提示中枢PVN微注射TRH对胃运动的增强作用,由迷走神经传出,且经M受体介导.
Microinjoction of thy-rotropin-releasing hormone (TRH) into par-avemricular nucleus (PVN ) obiviously increased gastric motility: frequency of gastric motility change from 3~1 times · min-1 to 6 ~ 8 times · min-1. intergastric pressure (IGP) rose from 0. 49 ± 0. 01kPa to 1. 9 1 ± 0. 5kPa. (P< 0. 001 ). Change rate of IGP was 290 Latent period of TGP change was about 8-10.IGP was restored in 70~90
min. Propranolol and regetine im could did not change the effects of TRH. Vagotomy and at-ropine im could block the effect of TRH in PVN on gastric motility. The results showed that microinjection of TRH into PVN enhanced gastric motility by way of vagus and M-receptor.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第6期463-465,470,共4页
Chinese Pharmacological Bulletin
