1-(2,6-二甲基苯氧基)-2-(3,4-二甲氧基苯乙氨基)丙烷盐酸盐对大鼠及肝硬化模型犬门静脉血液动力学的影响

Effects of l-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino) propane hydrochloride on the portal hemodynamics in normal rats and cirrhotic dogs

本文观察了DDPH对正常大鼠及肝硬化模型犬门静脉血液动力学的影响,发现DDPH能阻断α_1受体激功剂脱羟肾上腺素(Phen)对大鼠门静脉血管床的收缩作用,DDPH能明显降低肝硬化犬的门静脉血管阻力及门静脉压力,结果证明肝脏门静脉血管床以α_1受体调节为主,DDPH通过阻断门静脉血管床的α_1,受体,而发挥其降低犬硬化肝脏的门静脉血管阻力及门静脉压力的作用。

l-(2,6-dimethylphenoxy)-2-(3, 4-dimethoxyphenylethylamino) propane hydrochloride (DDPH) is a new synthetic compound with the selective α1 adrenoceptor blocking effects and calcium antagonistic action. The effects of DDPH on portal hemodynamics were studied in the normotensive Wistar rats and cirrhotic dogs. DDPH (4 mg·kg-1 iv) could completely antagonize the contractive effects of phenylephrine (0.4 mg·kg-1 iv) on the portal vascularbeds in rats. DDPH (0.5 mg·kg-1 iv infusion) decreased the portal vein resistence and lowered portal hypertension significantly in the cirrhotic dogs. However, there were no significant changes in hepatic arterial and portal vein blood flow in the cirrhotic dogs.The results indicated that in the portal vascular beds the physiological contractive function was mediated mainly by a, adrenoceptors. DDPH which has both the a, adrenoceptor blocking effect and the calcium antagonistic action could reduce the portal vein resistence and portal hypertension. The latter effect may have clinical significance in portal hypertension.