对氨基水杨酸钠对锰中毒大鼠体内锰,铜水平的影响

Effect of PAS-Na on the levels of manganese and copper in brain, liver and serum of manganese-poisoned rats

本文报道对氨基水杨酸钠(PAS-Na)对亚急性锰中毒大鼠不同脑区,肝和血清中锰,铜含量的影响,大鼠每日ip二氯化锰15 mg·kg^(-1),连续60或84 d;接着,每日ip PAS-Na 80或120 mg·kg^(-1),连续16或21 d,结果表明,锰中毒大鼠体重增加明显减少,脑和肝中锰,铜含量明显增加,以纹状体的锰,铜含量增加最多,锰中毒后PAS—Na治疗可以使脑,肝的锰含量减少,尤以d 78时所观察到的效果更为明显,提示PAS—Na有促排锰作用。

The ability of sodium p-amino salicylate (PAS-Na) to mobilize manganese and copper from the different brain regions (cerebral cortex,cerebellum, striatum and brain stem), liver and serum of rats given intraperitoneally MnCl2 ·4H2O (15 mg·kg-1) daily for 60 or 84 d was evaluated. The rats were treated on 16 or 21 consecutive days with ip PAS-Na at 80 or 120 mg·kg-1. The normal weight gain of the manganese administered rats was evidently reduced, but the proportion of the brain to the body weight as a whole was unaffected among the groups. The content of manganese and copper in the rat brain and liver was significantly increased by subchronic administration of manganese, with the highest content found in striatum.The treatment with PAS-Na decreased the level of manganese in the rat brain and liver in the same groups, specifically on d 78 suggesting that PAS-Na is capable of removing manganese significantly from the two organs.